Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report

Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report

Blog Article

Nowadays, the misuse of benzodiazepines (BZDs) is a cause for a serious concern among pharmacologically inexperienced patients, whether treated or untreated, that could lead to significant complications, including tolerance, dependence, and addiction.We present a case report in which an Italian patient affected by anxiety disorder and Lower Basket Rack Clip treated with BZDs presented a severe case of dependence on BZDs.We treated him according to an agonist substitution approach, switching from the abused BZD to a slow-onset, long-acting, high potency agonist (clonazepam), and looking at the methadone treatment model as paradigm.We decided to use clonazepam for its pharmacokinetic properties.The advantage of choosing a slow-onset, long-lasting BZD for the treatment of our patient was that it led us to a remarkable improvement in the hot water bottle clinical situation, including the cessation of craving, absence of withdrawal symptoms, reduced anxiety, improvements in social functioning, and a better cognition level.